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Hextan: Losartan is contraindicated in patients who are hypersensitive to any component of this product.
Hextan Plus: Hypersensitivity to losartan, sulphonamide-derived substances (as hydrochlorothiazide) or to any of the excipients.
Therapy resistant hypokalaemia or hypercalcaemia.
Severe hepatic impairment; Cholestasis and biliary obstructive disorders.
Refractory hyponatraemia.
Symptomatic hyperuricaemia/gout.
2nd and 3rd trimester of pregnancy.
Severe renal impairment (i.e. creatinine clearance <30 ml/min).
Anuria.
The concomitant use of Losartan/Hydrochlorothiazide with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m2).
